Rutin and or hesperidin, when low, frequently result in predictable, and even side-specific medical problems that include a greater risk for vascular degeneration, bruising capillary fragility, nose bleeds, varicose veins, periodontal bleeding, hemorrhoids and aneurism, with few individuals exhibiting optimal levels, despite mega-supplementation. One reason is the chemical interaction of other nutrients with flavonoids which can have a synergistic, or inhibiting effect. Various drugs also interact with bioflavonoids and affect their efficacy... Full Text